study of side effect of glucocorticoid in asthma patients at Allergic - MDLS Department of Bach mai hospital

Retrospective study on 1026 patients with asthma at Bach Mai Hospital from 1 January 1998 to 31 January 2002. Among them, 69.4% were 21 to 50 years old, with no different in sex. Hospitalized rate was highest in annual November. Glucocorticoid was used in all these patients with common kinds as solu-medrol: 76.2%; prednisolone: 67.7%; depersolone: 44.3% và Pulmicort: 7.6%. Rate of complication related to glucocorticoids was 28.7%. There were 24 types of symptom, including high blood glucose (11.5%), hypokaliemia (9.45%), hypertension (3.45%), gastric ulcer (2.83%), Cushing syndrome (2.53%). 7 systems damaged were endocrine (27.54%), musculoskeletal (4.28%), skin and mucous membrane (3.19%), gastrointestinal (4.96%), cardiovascular (3.7%), nervous and sense organs. There were 10 kinds of diseases and syndroms related to glucocorticoid use: hypertension, gastric ulcer, Cushing syndrome, diabetes, ponosis, retarded development, urticaria, anapphylactic shock, cataract, metal disorders, secondary bacterial contamination

To study allergic dermatitis of in-patients at the Department of Allergology and Clinical Immunology in Bach Mai Hospital (1999-2003)

There were 52 patients (30 females and 22 males) suffered from allergic dermatitis admitted to at the Department of Allergology and Clinical Immunology in Bach Mai Hospital (1999-2003). The results showed that: Antibiotic use is main cause of alergic dermatitis, in which phenicol class related to most cases. There were 4 main symptoms of allergic dermatitis: itching, erythema, oedema and vesicle. Symptoms always happened lately. Glucocorticoids, antihistamins and vitamin C are main medications to treat patients with allergic dermatitis.

Study on allergic reactions due to tubecular treatment medications for tubecular patients at the national hospital of tuberculosis and lung diseases (1998-2003)

Tuberculosis treatment-related allergic reactions are increasing. It influenced to therapy regimen for tubeculosis over our country. Objectives: (1) Make a list of tuberculosis treatments can cause allergic reactions. (2) Study on clinical symptoms of tuberculosis treatment allergy in tubeculosis patients. (3) Study on some of liver biochemical test. Subjects and method: 91 patients who had allergic reactions related to tuberculosis treatments presented between 1998 and 2003 in the National Hospital of Tubeculosis and Lung Diseases. Cross sectional survey and retrospective study. Results: There are 6 tuberculosis treatments related to allergic reactions: rifampicin, streptomycin, ethambutol, isoniazid, pyrazynamid and RH; Rifampicin, streptomycin and ethambutol are main cause. Most of all allergic reations happened late (after 24 hours) in patients with lung tuberculosis treated by "formula I". Out of 7 signs of allergic reaction, 3 clinical symptoms happened most are erythema, prurigo and fever. Delayed type of allergy is main part. Erythema is the main clinical form. There were no changes in AST, ALT and total bilirubin on blood test. Conclusion: Tuberculosis treatment of "formula I" are main cause of allergic reactions with various clinical symptoms and it can damage liver cells.

Study on Stevens – Johnson syndrome (SJS) and Lyell syndrome (TEN) due to allergy of medication at the Department of Allergology and Clinical immunology in Bach Mai Hospital (1997-2002)

Study on 98 patients with SJS and Lyell were treated at the Department of Allergology and Clinical immunology in Bach Mai Hospital (1997-2002). SJS & TEN always occurred when patients used the ampicillin and antibiotics of beta-lactam family, carbamazepine and anti-convulsion drugs properly or not. The symptoms of SJS & TEN appeared late (1-7 days) with 9 common clinical symptoms such as mucous membrane ulcerations, erythema, bullas and fever, etc. SR, uremia, enzymes of liver cells and proteinuria went up, that were main changes in blood test and urine test of SJS & TEN patients. Treating time was long-lasting, for SJS was 14.298.83 days, for Lyell syndrome is 19.716.6 days, with 4 main drugs: methyl-prednisolon, dimedrol, glycerin borate, and 5% glucose solution. There was no dead at that time.

Study on allergic reactions due to specific for gout's treatment at the department of allergology and clinical immunology of Bach Mai hospital

Author studied 21 allergic patients due to specific for Gout'streatment from 1995 to 2001 at the Department of Allergology and Clinical Immunology of Bach Mai Hospital with method "cross- sectional surveys". Results showed that: - Allopurinol, colchicin and both go together are specific for Gout'streatment and It caused of. allergic reactions of 21 patients. - Main symptoms of allergic patients of specific for Gout'streatment were erythema, itching and fever The main clinical form is Erythrodermie; Allergic reations were mostly nappened late (after 24 hours); Elevated ESR, white blood cell, uremia, SGOT SGPT and proteinuria are main changes of tests. -It takes a long time to treat allergic patients (13,54 :t 10,17 days); Solution of methyl-prednisolon and dimedrol are common medications to treat this patients; No allergic patient is died due to the specific for Gout'streatment at The Departma

Adverse drug reactions of glucocorticoid to asthmatic patients at the department of allergology and clinical immunology in Bach Mai Hospital (1998-2002)

GC is wonderful drug to prevent and control bronchial asthma. Methods: 1026 inpatients with asthma presented at the Department of Allergy and Clinical Immunology were included in this study. Cross - sectional surveys and retrospective studies. Objectives: Study on situation of using GC of asthmatic patients. Describe adverse drug reactions of glucocorticoid to asthmatic in - patients at the Department of Allergy and Clinical Immunology. Results: All of 1026 patients used Gc. Prednisolon, solu - medrol, depersolon and pulmicort were most used medications. There were 295 asthmatic patients have side effects (28.75%) with 24 types of symptom, 15 diseases and syndromes are resulted: Cushing syndrome, gastric ulcer, diabetes, hypertension, ponosis, retarded development... Almost systemic organs of the patients were influenced negatively by Gc. It has relationship among the way to use, the time in used GC and adverse drug reactions of GC. Conclusions: GC caused many adverse drug reactions to asthmatic patients.

Studies on uticaris and quincke edema due to allergy of medications

Studies on uticaris and quincke edema due to allergy of medications at the ward of Allergology and clinical immunology of Bach mai hospital (1991-2000). Result showed that: almost medications are used in medical clinic can cause allergic reactions. There were 393 kinds of medication that caused allergic reaction on 375 patients. In 23 different groups of medication. Antibiotics were main cause (67.2%) of allergic reactions, Beta-lactam class is 60.6% in the antibiotic group. besides urticaria and Quincke edema, there are many other clinical symptoms of allery from 375 in-patients: fever, erythema, dermatitis, dispnea. Allergic reactions were happened early (before 24 hours). Elevated ESR, white blood cell are main changes of teast. It takes short time to treat allergic patients (7.9 to 5.6 days). Solution of Methyl-Prednisolon, Dimedrol, Ascorbic acid and glucose 5% are common medications to treat this patients. No death occurred in patients of urticaria and Qincke edema during study periof.

Study on allergic reactions of cosmetic products at Department of Allergology – Clinical Immunology and National Institute of Dermatology and Venerology in Bach Mai Hospital

Retrospective and cross-sectional study on 60 patients with cosmetic allergy treated at Department of Allergology – Clinical Immunology and National Institute of Dermatology and Venerology in Bach Mai Hospital between January 1992 and February 2004. Results: there are plentiful and diversified cosmetics caused allergic reactions with 30 types divided into 6 groups: skin care cream (33.3%), dye hair (20.0%), powder foundation, toilet soap, other creams (21.7%), and other cosmetics. Allergic reactions commonly occurred in females, with common clinical symptoms such as itching, erythema, prurigo, vesicle, infected vesicle, edema, etc. They were treated by corticosteroid, anti-histamine H1, antibiotics, solution infusion, vitamin and other drugs. There was no death or more serious allergic reactions.

To study on some methods of diagnosis and treatment of iatrogenic allergy at the Department of allergy and clinical immunology in BachMai Hospital

At the Department of Allergy and Clinical immunology of Bach Mai Hospital from the year 1981 – 2003, study was performed in vivo on 1.728 patients of drug allergy and a control group of 143 healthy students without allergic history. Results showed that the positive rate of mastocyte degenerative reaction was 81.2%, of the test of lymphocyte transformation was 76.2%, applicated skin test was 66.7%. The highly accurate test such as the total IgE quantification and the determination of the number of thrombocyte in the forth of T lymphocyte were recommended for complementing, the diagnosis and for minotring the treatment of drug allergy. Methyl-prednisolon, Dimedron, vitamin C and glucose solution were the main medication for allergic control. Patients with Stevens-Johnson and Lyell syndromes required special cares such as for burn, preliminary good results were given for 100% of patients. Mean duration of the course of treatment got 9.6 6.8 days and for Stevens-Johnson syndrome 16.1  9.5 days.

To investigate the causes and the clinical characteristics of iatrogenic allergy at the Department of allergy and clinical immunology in BachMai Hospital

At the Department of Allergy and Clinical Immunology of Bach Mai Hospital in 1981-2003 year period, 1.728 patients with drug allergy and a controll group including 143 healthy students without allergic history were enrolled into study. Almost drug had been used in consultative clinic could make allergic reaction. 128 type of medicines could make diverse allergic reactions on 1.728 patients. Among 27 groups of medicine, antibiotics were the main caused with 72.4%. The main clinical symptoms of drug allergy in 615 inpatients were itchi, fever, dizzi, uncomfortable feeling and urticaria and some dangerous symdroms as Stevens-Johnson and Lyell syndrome.

Study on acute urticaria syndrome due to drug allergy of in-patient at the Department of Allergology and Clinical Immunology of Bach Mai Hospital (2001-2005)

The cross sectional study was conducted in 111 patients suffered from acute urticaria due to drug allergy at the Department of Allergology and Clinical Immunology of Bach Mai Hospital from January 2001 to May 2005. Results: these patients were allergic to 120 kinds of medications; antibiotic were the leading cause of the acute urticaria with 55.8%, among which beta lactam is the most common cause; then traditional medications with 15.8% … Patients often included 2 groups: <20 and 20-39 years (34.2%), women more than men (p<0.005). The rate of oral allergy accounted for 88.3%; 50.4% of patients had allergic history. Allergy to one kind of medication 91.9%. The duration of acute urticaria was from 1 to 24 hours (48.6%). Increase of erythrocyte sedimentation rate occurred in 62.2% of patients. The duration of treatment was 6.57±3.56 days. The patients were treated with glucocorticoid and antihistamine, mainly methyl-prednisolon and dimedrol. 100% of patients recovered